01 - Whisk buttermilk, salt, black pepper, garlic powder, and paprika in a large bowl. Add chicken breasts and turn to coat evenly. Cover and refrigerate for at least 30 minutes up to 4 hours for maximum tenderness.
02 - Combine flour, panko breadcrumbs, paprika, cayenne pepper, oregano, salt, and black pepper in a shallow dish.
03 - Remove chicken breasts from marinade, letting excess drip off. Dredge thoroughly in the coating mixture, pressing gently to ensure adherence.
04 - Warm vegetable oil in a large nonstick or cast-iron skillet over medium-high heat until shimmering.
05 - Place chicken in the skillet and cook for 5–6 minutes per side until golden brown and internal temperature reaches 165°F. Adjust heat as necessary to avoid burning.
06 - Transfer chicken to a plate lined with paper towels to remove excess oil. Allow to rest for 5 minutes before serving.