01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, pepper, smoked paprika, and garlic powder. Break up the meat with a spatula and stir occasionally until browned and cooked through, about 7–8 minutes. Drain excess fat if needed.
02 - While the beef cooks, whisk together the mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper in a small bowl until well combined. Set aside.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls to create the base.
04 - Top each lettuce bowl with equal portions of the cooked ground beef, cherry tomatoes, shredded cheddar cheese, red onion, pickle slices, and diced avocado.
05 - Drizzle the prepared burger sauce over each bowl just before serving.
06 - Serve immediately while the beef is still warm.