01 - Set oven temperature to 350°F and grease a 2-quart baking dish.
02 - Boil elbow macaroni in salted water until just al dente. Drain and set aside.
03 - Melt 1/4 cup unsalted butter in a saucepan over medium heat. Whisk in 1/3 cup flour and cook for 1 to 2 minutes until bubbling without browning.
04 - Gradually whisk in 3 cups whole milk, stirring constantly until smooth. Cook for 4 to 5 minutes until thickened.
05 - Remove from heat and stir in Dijon mustard, garlic powder, onion powder, salt, and black pepper.
06 - Add grated sharp cheddar and mozzarella cheeses, stirring until melted and smooth.
07 - Mix the cooked macaroni with the cheese sauce and transfer to the prepared baking dish.
08 - Combine breadcrumbs, melted butter, and Parmesan cheese. Evenly sprinkle over the macaroni mixture.
09 - Bake in the preheated oven for 25 to 30 minutes until the topping is golden and bubbling.
10 - Allow the dish to rest for 10 minutes before serving.